Fc epsilon RI signaling pathway
| PAG Title | Fc epsilon RI signaling pathway |
| PAG ID | WAG000811 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | Fc epsilon RI-mediated sigling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous sigling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses. |
| Species | Homo sapiens |
| nCoCo Score | 4,976 |
| Base PAG ID | WAG000811 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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